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ifnλ3  (R&D Systems)


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    Structured Review

    R&D Systems ifnλ3
    Ifnλ3, supplied by R&D Systems, used in various techniques. Bioz Stars score: 94/100, based on 37 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/ifn%CE%BB3/Recombinant+Human+IL-28B%2FIFN-lambda+3+Protein/pmc12846703-10-10-12
    Average 94 stars, based on 37 article reviews
    ifnλ3 - by Bioz Stars, 2026-11
    94/100 stars

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    Related Articles

    Recombinant:

    Article Title: ERK5 Signaling is Required for Type III IFN-mediated Mucosal Antiviral Responses
    Article Snippet: BHK21 and MDCK cells were obtained from BEI resources and grown in EMEM supplemented with 10% FBS, 2mM Glutamine, 100 U/ml Penicillin and 100 mg/ml Streptomycin and maintained at 37°C in 5% CO 2 . .. Cells were stimulated with human recombinant IFNλ3 (R&D Systems) or murine recombinant IFNβ (R&D Systems) and IFNλ3 (R&D Systems) at the indicated concentrations. .. ERK5 kinase inhibitors, XMD8-85, JWG-071, and AX15836 (Cayman Chemicals), were reconstituted in DMSO and used at the indicated concentrations.

    Article Title: MEF2A suppresses stress responses that trigger DDX41-dependent IFN production
    Article Snippet: .. Cells were stimulated with recombinant IFNβ (PBL Assay Science) and IFNλ3 (R&D Systems) at the indicated concentrations. .. Cells were stimulated with recombinant IFNβ (PBL Assay Science) and IFNλ3 (R&D Systems) at the indicated concentrations.

    Article Title: MEF2A suppresses replicative stress responses that trigger DDX41-dependent IFN production
    Article Snippet: .. Cells were stimulated with recombinant IFNβ (PBL Assay Science) and IFNλ3 (R&D Systems) at the indicated concentrations. .. Specific kinase inhibitors targeting, ATR (ETP-46465, AZD6738) (Cayman Chemicals), ATM (KU-55933) (SelleckChem), DNA-PK (NU7441) (SelleckChem), and TBK1 (GSK8612) were used at the indicated concentrations (Supplementary Table 2).

    Activity Assay:

    Article Title: Highly-sensitive reporter cell line for detection of interferon types I-III and their neutralization by antibodies
    Article Snippet: .. For detection of IFN activity by A549-IFN-reporter (AIR) cells, 30,000 cells per well were seeded in a 96-well white-bottomed tissue culture plate and stimulated 24h later with IFNα2 (Novusbio; NPB2-34971), IFNβ (pbl assay science; 11420-1), IFNω (Novusbio; NBP2-35893), IFNγ (Novusbio; NBP2-34992), IFNλ1 (Novusbio; NBP2-34996), IFNλ2 (R&D systems; 8417-IL), or IFNλ3 (R&D systems; 5259-IL) at the indicated concentrations. .. Additionally, live-cell Renilla luciferase substrate (EnduRen, Promega; E6481) was added at a 1:10,000 dilution.

    Produced:

    Article Title: Highly sensitive reporter cell line for detection of interferon types I–III and their neutralization by antibodies
    Article Snippet: .. For detecGon of IFN acGvity by A549-IFN-reporter (AIR) cells, 30,000 cells per well 49 were seeded in a 96-well white-boaomed Gssue culture plate and sGmulated 24h later with IFNα2 50 (Novusbio; NPB2-34971, produced in yeast cells), IFNβ (pbl assay science; 11420-1, produced in E. coli), 51 IFNω (Novusbio; NBP2-35893, produced in E. coli), IFNγ (Novusbio; NBP2-34992, produced in E. coli), 52 IFNλ1 (Novusbio; NBP2-34996, produced in E. coli), IFNλ2 (R&D systems; 8417-IL, produced in 293T 53 cells), or IFNλ3 (R&D systems; 5259-IL, produced in CHO cells) at the indicated concentraGons. .. 54 AddiGonally, live-cell Renilla luciferase substrate (EnduRen, Promega; E6481) was added at a 1:10,000 55 final diluGon.



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    (A) IFNβ and (B) <t>IFNλ3</t> proteins detected in top channel washes recovered at 4 days post-infection. (n=5 independent experiments with 5 different organoid lines. Each dot color represents an organoid line. Median +/- interquartile range are plotted and Kruskal-Wallis tests are used for addressing statistically significant differences).
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    Image Search Results


    (A) IFNβ and (B) IFNλ3 proteins detected in top channel washes recovered at 4 days post-infection. (n=5 independent experiments with 5 different organoid lines. Each dot color represents an organoid line. Median +/- interquartile range are plotted and Kruskal-Wallis tests are used for addressing statistically significant differences).

    Journal: bioRxiv

    Article Title: Modeling viral and bacterial infections in human lung organotypic systems reveals strain specific host responses

    doi: 10.1101/2025.03.31.644992

    Figure Lengend Snippet: (A) IFNβ and (B) IFNλ3 proteins detected in top channel washes recovered at 4 days post-infection. (n=5 independent experiments with 5 different organoid lines. Each dot color represents an organoid line. Median +/- interquartile range are plotted and Kruskal-Wallis tests are used for addressing statistically significant differences).

    Article Snippet: For the IFNλ3 assay, the 21730-1 IgG1, kappa, mouse monoclonal antibody (PBL Assay Science) was used as a capture antibody after coating on paramagnetic beads (0.3 mg.mL -1 ), the MAB52591R IgG2a, mouse monoclonal antibody (R&D Systems, Minneapolis, MN, USA) was biotinylated (biotin/antibody ratio = 60/1) and used as the detector antibody at a concentration of 0.3 μg.mL -1 , and the 5259-IL-025/CF recombinant human IFNλ3 protein (R&D Systems) was used as calibrator.

    Techniques: Infection